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KMID : 0358320090500121213
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Korean Journal of Urology
2009 Volume.50 No. 12 p.1213 ~ p.1218
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Effect of Tamsulosin and Dichlozid on the Expected Treatment of Ureteral Calculi
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Yoon Woon-Yong
Lee Sang-Ik
Jeong Tae-Yoong
Kim Dong-Jun
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Abstract
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Purpose: We evaluated the effect of tamsulosin and hydrochlorothiazide (Dichlozid) on the expulsion of ureteral stones.
Materials and Methods: A total of 132 patients with a single ureteral calculi less than 10 mm in diameter were enrolled and divided into 3 groups: group 1 (n=40) received tamsulosin (0.2 mg/day), group 2 (n=35) received Dichlozid (25 mg/day) and tamsulosin (0.2 mg/day), and group 3 (n=57) was the control. Proximal and distal ureteral stones were evaluated separately. Efficacy was evaluated in terms of the rate and duration of expulsion according to stone size (＜5 mm, ≥5 mm) for a maximum period of 4 weeks.
Results: The mean stone diameters were 4.9±1.7 mm (group 1), 4.8±1.6 mm (group 2), and 5.3±1.8 mm (group 3). The overall expulsion rates were 70%, 74.3%, and 52.6%, respectively, and showed statistical significance. The mean durations of expulsion were 14.7±1.6, 12.8±1.5, and 18.0±2.0 days, respectively, and group 2 showed a significant decrease in the duration. There were no significant differences in the expulsion rate of proximal and distal ureteral stones in any group. Distal ureteral stones in groups 1 and 2 showed a significant reduction in the mean expulsion time (＜5 mm: 13.6±0.5, 11.8±0.7, and 16.7±0.8 days in groups 1, 2, and 3, respectively; ≥5 mm: 15.0±1.4, 13.0±0.6, and 17.8±0.4 days in groups 1, 2, and 3, respectively). The mean expulsion time for smaller proximal stones (＜5 mm) in groups 1 and 2 was reduced significantly (17±0.6, 15.2±0.8, and 19.3±0.6 days in groups 1, 2, and 3, respectively).
Conclusions: Medical therapy with tamsulosin is time-saving and effective for treating ureteral calculi. In addition, adjunctive treatment with Dichlozid may reduce the duration of expulsion.
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KEYWORD
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Ureteral calculi, Tamsulosin, Diuretics
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